Some of the main causes of aging include accumulated cellular damage caused by reactive molecules known as free radicals and the shortening of telomere, NMN supplements are showing results for age reversal by fixing the structures located at the ends of chromosomes that play an important role in cellular division (research Source).
While aging is inevitable, increasing the healthy human lifespan and slowing the aging process has been a focus of scientific university research for decades.
Through that research, scientists have identified a large variety number of natural substances that have anti-aging properties, many of which can be taken as herbal supplements by those looking for natural holistic ways to decelerate the aging process and prevent age-related disease.
NMN and Resveratrol
A number of clinical research studies have shown positive results related to supplementing with both NR and NMN. However, more human research is needed before strong conclusions on the anti-aging effects of NR and NMN can be made (Research Studies,
David Sinclair, Harvard university researcher, describes resveratrol and NMN as critical for the activation of sirtuin genes. Sirtuins play a special role in functions that help us to live longer.
He describes resveratrol as the “gas pedal” for increasing sirtuin genes and NMN as the fuel. Without “fuel”, resveratrol won’t work. The reason that resveratrol supplements are not effective without pure NMN, is that sirtuin activation requires youthful NAD levels, but by 50 years old, we have about half the level of NAD we had in our 20s
So in effect, you take resveratrol supplements to increase activation of the sirtuin genes, and NMN to ensure the sirtuins have enough energy to work properly. Resveratrol for anti aging, is a molecule that’s found in the skin of foods like grapes, blueberries. Unfortunately all foods sources contain tiny amounts, so we need to take micronized Resveratrol it in a concentrated supplement form to achieve results
That’s a wordy quote from the paper, but in essence, they were testing a micronized resveratrol formulation against a non-micronized formula . Their study found that levels of resveratrol in the blood were 3.6x greater when using the micronized delivery vehicle , and other markers they were comparing also improved.
We see this with a variety of other molecules; where reducing particle size increases bioavailability. For example with curcumin, whose absorption can be improved through micronization. So this makes sense.